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Coagulation Factor Activation in Stored Platelet Concentrates is Modulated by the Platelets
- Source :
- Vox Sanguinis. 70:76-85
- Publication Year :
- 1996
- Publisher :
- Wiley, 1996.
-
Abstract
- To assess alterations in coagulation proteins in stored platelet concentrates, we used a series of platelet parameters and measures of coagulation activation to compare samples collected before unit donation, during the processing of platelet concentrates (PC) from CPDA-1 blood, and in storage up to 5 days as well as stored platelet-poor plasma (PPP). Storage-dependent increases in activated partial thromboplastin time and prothrombin time were seen in both PC and PPP. However, FVII, FXI, FXII, kallikrein activity and prothrombin F1.2 levels remained unchanged in stored PC. Surprisingly, in stored PPP, significant alterations in FXII, FVII, kallikrein and prothrombin F1.2 levels were seen. Platelet morphology and surface marker studies demonstrated platelet activation during storage. These data suggest that the presence of platelets in the CLX storage container partially suppresses coagulation activation at significant cost to platelet viability.
- Subjects :
- Blood Platelets
medicine.medical_specialty
Time Factors
Fluorescence
Flow cytometry
Blood product
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Platelet
Platelet activation
Blood Coagulation
Prothrombin time
medicine.diagnostic_test
Chemistry
Kallikrein
Hematology
General Medicine
Flow Cytometry
Blood Coagulation Factors
Endocrinology
Coagulation
Biochemistry
Blood Preservation
Partial thromboplastin time
Subjects
Details
- ISSN :
- 14230410 and 00429007
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Vox Sanguinis
- Accession number :
- edsair.doi.dedup.....b1d0b6657e8e085badc99d292220fa7a
- Full Text :
- https://doi.org/10.1159/000462088