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Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series
- Source :
- Digestive Diseases and Sciences. 61:2741-2748
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Herbal and dietary supplement (HDS) hepatotoxicity is increasingly being reported in the USA. This case series describes the presenting clinical features and outcomes of seven patients with liver injury attributed to OxyELITE Pro enrolled in the Drug-Induced Liver Injury Network (DILIN) study. The 6-month outcomes of patients with hepatotoxicity attributed to OxyELITE Pro enrolled in the DILIN prospective registry between 2004 and 2015 are presented. Six of the seven patients (86 %) presented in 2013 with symptoms of hepatitis and acute hepatocellular injury. The median duration of OxyELITE Pro use was 18 weeks (range 5–102 weeks). Median age was 36 years (range 28–62), 86 % were female, and 43 % were Asian. One patient had rash, none had eosinophilia, and three had antinuclear antibody reactivity. The median peak ALT was 2242 U/L, alkaline phosphatase 284 U/L and bilirubin 15.0 mg/dL. Six patients (86 %) were hospitalized, three developed acute liver failure and two underwent liver transplantation. DILIN causality scores for OxyELITE Pro were definite in 1, highly likely in 3, probable in 2, and possible in 1. Four of the five patients without liver transplant recovered completely within 6 months, while one patient had mild residual ALT elevations. Seven cases of severe acute hepatocellular injury attributed to OxyELITE Pro are reported. These results reinforce the need to assess for HDS supplement use in patients presenting with unexplained acute hepatitis and point to the need for additional regulatory oversight of HDS products.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Anti-nuclear antibody
Physiology
Bilirubin
medicine.medical_treatment
Liver transplantation
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
Eosinophilia
Prospective Studies
Registries
Liver injury
Hepatitis
business.industry
Alanine Transaminase
Liver Failure, Acute
Middle Aged
Hepatology
Alkaline Phosphatase
medicine.disease
Amides
Rash
United States
Liver Transplantation
Surgery
chemistry
Antibodies, Antinuclear
030220 oncology & carcinogenesis
Dietary Supplements
Female
030211 gastroenterology & hepatology
Plant Preparations
Chemical and Drug Induced Liver Injury
medicine.symptom
business
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi.dedup.....b2054d73da8a14b8442c7aef0ae656e4