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Immunoselection techniques in hematopoietic stem cell transplantation
- Source :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 54(3)
- Publication Year :
- 2016
-
Abstract
- Hematopoietic Stem Cells Transplantation (HSCT) is an effective treatment for hematological and non-hematological diseases. The main challenge in autologous HSCT is purging of malignant cells to prevent relapse. In allogeneic HSCT graft-versus-host disease (GvHD) and opportunistic infections are frequent complications. Two types of graft manipulation have been introduced: the first one in the autologous context aimed at separating malignant cells from hematopoietic stem cells (HSC), and the second one in allogeneic HSCT aimed at reducing the incidence of GvHD and at accelerating immune reconstitution. Here we describe the manipulations used for cell purging in autologous HSCT or for T Cell Depletion (TCD) and T cell selection in allogeneic HSCT. More complex manipulations, requiring a Good Manufacturing Practice (GMP) facility, are briefly mentioned.
- Subjects :
- medicine.medical_treatment
Graft vs Host Disease
chemical and pharmacologic phenomena
Context (language use)
Hematopoietic stem cell transplantation
Biology
Lymphocyte Depletion
03 medical and health sciences
0302 clinical medicine
Immune system
immune system diseases
hemic and lymphatic diseases
medicine
Humans
Autografts
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cell
Hematology
medicine.disease
Allografts
Hematopoietic Stem Cells
Transplantation
Haematopoiesis
surgical procedures, operative
Graft-versus-host disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
Immunology
Stem cell
therapeutics
030215 immunology
Subjects
Details
- ISSN :
- 14730502
- Volume :
- 54
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
- Accession number :
- edsair.doi.dedup.....b206a66602b600ff4acbf0d275ffd7d1