Study of individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip

Authors :: Lihong Liu
Sha Huang
Jongyoon Han
Xiaoying Xu
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Liu, Lihong
Huang, Sha
Han, Jongyoon
Source :: Scientific Reports, Nature Publishing Group
Publication Year :: 2016
Publisher :: Nature Publishing Group, 2016.
Abstract: Human red blood cells (RBCs) deformability in vitro was assessed during iron dextran (INFeD) loading and/or ethanol co-administration using microfluidic deformability screening. The results showed donor-specific variations in dose dependent deformability shift were revealed below 500 μg/mL iron dextran. Two out of nine blood samples exhibited significant cell stiffening at 500 μg/mL iron dextran loading concentration (p<br />Singapore-MIT Alliance in Research and Technology (SMART)

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