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Gut micro flora in genesis of methilthyo metabolites of paracetamol

Authors :
P Vera Gusman
Momir Mikov
P Maja Djanic
M Gordana Smiesko
Source :
Zbornik Matice Srpske za Prirodne Nauke, Vol 2019, Iss 137, Pp 43-47 (2019)
Publication Year :
2019
Publisher :
Matica srpska, 2019.

Abstract

Gut micro flora represents a system of extensive metabolic capacity which is quite different when compared to other cells of body and organs. In recent times, there has been an evidence of very important role of gut cysteine conjugate beta-lyases in metabolism of cystein conjugates. A lot of studies are dedicated to exploration of the role of gut micro flora in formation of methylthio adducts from paracetamol in conventional mice and those treated with neomycin as our study. A highly significant reduction in urinary excretion of 3-methylthioparacetamol in group of neomycin-treated mice was confirmed as well its glucuronic acid and sulphate conjugates. Following the principal role of gut flora in the C-S cleavage of paracetamol l-3-cyctein it is clear that highest concentration of methylthio adducts from paracetamol are presented in pretreated mice.

Details

Language :
English
ISSN :
03524906
Volume :
2019
Issue :
137
Database :
OpenAIRE
Journal :
Zbornik Matice Srpske za Prirodne Nauke
Accession number :
edsair.doi.dedup.....b20ec3e45213714224ea95049c7cbcfb