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Green tea and its anti-angiogenesis effects
- Source :
- Biomedicine & Pharmacotherapy. 89:949-956
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The development of new blood vessels from a pre-existing vasculature (also known as angiogenesis) is required for many physiological processes including embryogenesis and post-natal growth. However, pathological angiogenesis is also a hallmark of cancer and many ischaemic and inflammatory diseases. The pro-angiogenic members of the VEGF family (vascular endothelial growth factor family), VEGF-A, VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF), and the related receptors, VEGFR-1, VEGFR-2 and VEGFR-3 have a central and decisive role in angiogenesis. Indeed, they are the targets for anti-angiogenic drugs currently approved. Green tea (from the Camellia sinensis plant) is one of the most popular beverages in the world. It is able to inhibit angiogenesis by different mechanisms such as microRNAs (miRNAs). Green tea and its polyphenolic substances (like catechins) show chemo-preventive and chemotherapeutic features in various types of cancer and experimental models for human cancers. The tea catechins, including (-)-epigallocatechin-3-gallate (EGCG), have multiple effects on the cellular proteome and signalome. Note that the polyphenolic compounds from green tea are able to change the miRNA expression profile associated with angiogenesis in various cancer types. This review focuses on the ability of the green tea constituents to suppress angiogenesis signaling and it summarizes the mechanisms by which EGCG might inhibit the VEGF family. We also highlighted the miRNAs affected by green tea which are involved in anti-angiogenesis.
- Subjects :
- 0301 basic medicine
Placental growth factor
Angiogenesis
Biology
Catechin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
microRNA
medicine
Animals
Humans
Receptor
Pharmacology
Neovascularization, Pathologic
Tea
Vascular Endothelial Growth Factors
food and beverages
Cancer
General Medicine
Vascular Endothelial Growth Factor Family
medicine.disease
MicroRNAs
030104 developmental biology
chemistry
Biochemistry
030220 oncology & carcinogenesis
Proteome
Cancer research
Subjects
Details
- ISSN :
- 07533322
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....b2165a168353104b9b8bd1d9cc334703