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Defined cell adhesion for silicon-based implant materials by using vapor-deposited functional coatings
- Source :
- Colloids and Surfaces B: Biointerfaces. 175:545-553
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The field of implantable electronics relies on using silicon materials due to the merits of a well-established fabrication process and favorable properties; of particular interest is the surface modification of such materials. In the present study, we introduce a surface modification technique based on coatings of functionalized Parylene on silicon substrates, where the modified layers provide a defined cell adhesion capability for the resultant silicon materials/devices. Functionalization of Parylene was achieved during a one-step chemical vapor deposition (CVD) polymerization process, forming NHS ester-functionalized Parylene, and subsequent RGD attachment was enabled via a conjugation reaction between the NHS ester and amine groups. The modification procedures additionally provided a clean and gentle approach to avoid thermal excursions, intense irradiation, chemicals, or solvents that might damage delicate structures or sensitive molecules on the devices. The modification layers exhibited excellent mechanical strength on the substrate, meeting the high standards of the American Society for Testing and Materials (ASTM), and the resultant cell adherence property was verified by a centrifugation assay and the analysis of attached cell morphologies; the results collectively demonstrated robust and sustainable modification layers of the NHS ester-functionalized Parylene and confirmed that the cell-adherence property imparted by using this facile modification technique was effective. The modification technology is expected to benefit the design of prospective interface properties for silicon-based devices and related industrial products.
- Subjects :
- Silicon
Fabrication
Materials science
Cell Survival
Polymers
Surface Properties
chemistry.chemical_element
Nanotechnology
02 engineering and technology
Substrate (electronics)
Chemical vapor deposition
Xylenes
01 natural sciences
Cell Line
Mice
Structure-Activity Relationship
chemistry.chemical_compound
Colloid and Surface Chemistry
Coated Materials, Biocompatible
Parylene
0103 physical sciences
Cell Adhesion
Animals
Molecule
Physical and Theoretical Chemistry
Cell Proliferation
010304 chemical physics
Epithelial Cells
Esters
3T3 Cells
Prostheses and Implants
Surfaces and Interfaces
General Medicine
021001 nanoscience & nanotechnology
Electronics, Medical
chemistry
Polymerization
Surface modification
Volatilization
0210 nano-technology
Oligopeptides
Biotechnology
Subjects
Details
- ISSN :
- 09277765
- Volume :
- 175
- Database :
- OpenAIRE
- Journal :
- Colloids and Surfaces B: Biointerfaces
- Accession number :
- edsair.doi.dedup.....b2210db639be65370e7f97e8369828f8