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Shared neoantigens: ideal targets for off-the-shelf cancer immunotherapy
- Source :
- Pharmacogenomics. 21:637-645
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Neoantigen, as an important member of tumor-specific antigens, has attracted a great deal of attention as a target for immunotherapy. Neoantigens are potential targets for personalized vaccines and adoptive cell transfer therapies. However, most of the neoantigen-targeted immunotherapies in the process are customized and costly. So, we are inclined to find shared neoantigens suitable for more patients. With the help of existing neoantigen prediction algorithms, we found that the most frequent shared neoantigens occurred in more than 1% of patients for 17 tumor types and the ten most frequent shared neoantigens covered approximately 50% of pancreatic cancer patients, providing a potential list of targets for off-the-shelf immunotherapy.
- Subjects :
- 0301 basic medicine
Adoptive cell transfer
medicine.medical_treatment
Antineoplastic Agents
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
Cancer immunotherapy
Antigens, Neoplasm
Neoplasms
Pancreatic cancer
Genetics
Humans
Medicine
Off the shelf
Precision Medicine
Pharmacology
Ideal (set theory)
integumentary system
business.industry
Immunotherapy
medicine.disease
Prediction algorithms
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
business
Subjects
Details
- ISSN :
- 17448042 and 14622416
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Pharmacogenomics
- Accession number :
- edsair.doi.dedup.....b234dc3a588b552d770e4e3094c5cc8d