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Intensive Medical Nutrition Therapy Alone or with Added Metformin to Prevent Gestational Diabetes Mellitus among High-Risk Mexican Women: A Randomized Clinical Trial
- Source :
- Nutrients, Nutrients, Vol 14, Iss 62, p 62 (2022), Nutrients; Volume 14; Issue 1; Pages: 62
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The aim of this study was to examine the efficacy of intensive medical nutrition therapy (MNT) plus metformin in preventing gestational diabetes mellitus (GDM) among high-risk Mexican women. An open-label randomized clinical trial was conducted. Inclusion criteria were pregnant women with three or more GDM risk factors: Latino ethnic group, maternal age >35 years, body mass index >25 kg/m2, insulin resistance, and a history of previous GDM, prediabetes, a macrosomic neonate, polycystic ovarian syndrome, or a first-degree relative with type 2 diabetes. Women before 15 weeks of gestation were assigned to group 1 (n = 45): intensive MNT-plus metformin (850 mg twice/day) or group 2 (n = 45): intensive MNT without metformin. Intensive MNT included individual dietary counseling, with ≤50% of total energy from high carbohydrates. The primary outcome was the GDM incidence according to the International Association of Diabetes Pregnancy Study Groups criteria. There were no significant differences in baseline characteristics and adverse perinatal outcomes between the groups. The GDM incidence was n = 11 (24.4%) in the MNT plus metformin group versus n = 7 (15.5%) in the MNT without metformin group: p = 0.42 (RR: 1.57 [95% CI: 0.67–3.68]). There is no benefit in adding metformin to intensive MNT to prevent GDM among high-risk Mexican women. Clinical trials registration: NCT01675310.
- Subjects :
- Adult
obesity
endocrine system diseases
Adolescent
diet
pregnancy
gestational weight gain
gestational diabetes
Article
Body Mass Index
Young Adult
Pregnancy
Humans
Hypoglycemic Agents
TX341-641
Medical History Taking
Mexico
Nutrition and Dietetics
Nutrition. Foods and food supply
Infant, Newborn
nutritional and metabolic diseases
Middle Aged
Metformin
Pregnancy Complications
Diabetes, Gestational
Female
Nutrition Therapy
Food Science
Maternal Age
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....b237227acf8eca9f6f551358a2e06fa2