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Fructose- 1,6-Bisphosphate Supports Cerebral Energy Metabolism in Pigs after Ischemic Brain Injury Caused by Experimental Particle Embolization
- Source :
- The Heart Surgery Forum. 9:E828-E835
- Publication Year :
- 2006
- Publisher :
- Carden Jennings Publishing Co., 2006.
-
Abstract
- Background. Fructose-1,6-bisphosphate (FDP) is a high-energy intermediate that enhances glycolysis, preserves cellular adenosine triphosphate stores, and prevents the increase of intracellular calcium in ischemic tissue. Since it has been shown to provide metabolic support to the brain during ischemia, we planned this study to evaluate whether FDP is neuroprotective in the setting of combining hypothermic circulatory arrest (HCA) and irreversible embolic brain ischemic injury. Methods. Twenty pigs were randomly assigned to receive 2 intravenous infusions of either FDP (500 mg/kg) or saline. The first infusion was given just before a 25-minute period of HCA and the second infusion immediately after HCA. Immediately before HCA, the descending aorta was clamped and 200 mg of albumin-coated polystyrene microspheres (250-750 mm in diameter) were injected into the isolated aortic arch in both study groups. Results. There were no significant differences between the study groups in terms of neurological outcome. Brain lactate/pyruvate ratio was significantly lower ( P = .015) and brain pyruvate levels ( P = .013) were significantly higher in the FDP group compared with controls. Brain lactate levels were significantly higher 8 hours after HCA ( P = .049). Conclusion. The administration of FDP before and immediately after HCA combined with embolic brain ischemic injury was associated with significantly lower brain lactate/pyruvate ratio and significantly higher levels of brain pyruvate, as well as lower lactate levels 8 hours after HCA. FDP seems to protect the brain by supporting energy metabolism. The neurological outcome was not improved, most likely resulting from the irreversible nature of the microsphere occlusion.
- Subjects :
- medicine.medical_specialty
Fructose 1,6-bisphosphate
Swine
medicine.medical_treatment
Ischemia
Neuroprotection
Calcium in biology
Brain Ischemia
chemistry.chemical_compound
Internal medicine
Pyruvic Acid
Fructosediphosphates
medicine
Animals
Glycolysis
Lactic Acid
Saline
business.industry
Brain
medicine.disease
Circulatory Arrest, Deep Hypothermia Induced
Disease Models, Animal
Neuroprotective Agents
Endocrinology
Intracranial Embolism
chemistry
Anesthesia
Circulatory system
Surgery
Energy Metabolism
Cardiology and Cardiovascular Medicine
business
Adenosine triphosphate
Subjects
Details
- ISSN :
- 15226662 and 10983511
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- The Heart Surgery Forum
- Accession number :
- edsair.doi.dedup.....b245014ab97b13cea4240875301f84bb
- Full Text :
- https://doi.org/10.1532/hsf98.20061079