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Garlic-DerivedS-allylmercaptocysteine Is a NovelIn vivoAntimetastatic Agent for Androgen-Independent Prostate Cancer
- Source :
- Clinical Cancer Research. 13:1847-1856
- Publication Year :
- 2007
- Publisher :
- American Association for Cancer Research (AACR), 2007.
-
Abstract
- Purpose: There is epidemiologic evidence that high garlic consumption decreases the incidence of prostate cancer, and compounds isolated from garlic have been shown to have cancer-preventive and tumor-suppressive effects. Recent in vitro studies in our laboratory have shown that garlic-derived organosulfur compound S-allylmercaptocysteine suppresses invasion and cell motility of androgen-independent prostate cancer cells via the up-regulation of cell-adhesion molecule E-cadherin. S-allylmercaptocysteine is therefore a potential antimetastatic drug with broad clinical applications that we tested in vivo for the first time in this study.Experimental Design: We used a newly established fluorescent orthotopic androgen-independent prostate cancer mouse model to assess the ability of S-allylmercaptocysteine to inhibit tumor growth and dissemination.Results: We showed that oral S-allylmercaptocysteine not only inhibited the growth of primary tumors by up to 71% (P < 0.001) but also reduced the number of lung and adrenal metastases by as much as 85.5% (P = 0.001) without causing notable toxicity. This metastatic suppression was accompanied by a 91% reduction of viable circulating tumor cells (P = 0.041), suggesting that S-allylmercaptocysteine prevents dissemination by decreasing tumor cell intravasation.Conclusions: Our results provide in vivo evidence supporting the potential use of S-allylmercaptocysteine as an E-cadherin up-regulating antimetastatic agent for the treatment of androgen-independent prostate cancer. This is the first report of the in vivo antimetastatic properties of garlic, which may also apply to other cancer types.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Antineoplastic Agents, Hormonal
Green Fluorescent Proteins
Drug Evaluation, Preclinical
Antineoplastic Agents
Mice, SCID
Transfection
Mice
Prostate cancer
Circulating tumor cell
In vivo
Internal medicine
Antimetastatic Agent
Tumor Cells, Cultured
medicine
Animals
Humans
Cysteine
Neoplasm Metastasis
Garlic
Dose-Response Relationship, Drug
business.industry
Intravasation
Prostatic Neoplasms
Cancer
medicine.disease
Xenograft Model Antitumor Assays
In vitro
Endocrinology
Oncology
Drug Resistance, Neoplasm
Androgens
Cancer research
business
Subjects
Details
- ISSN :
- 15573265 and 10780432
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Clinical Cancer Research
- Accession number :
- edsair.doi.dedup.....b254e9522a5071b20dd86e9abe46fd95