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Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort
- Source :
- EBioMedicine, Vol 76, Iss, Pp 103875-(2022), EBioMedicine, EBioMedicine, 2022, 76, pp.103875. ⟨10.1016/j.ebiom.2022.103875⟩
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- International audience; Background: Asthma is an inflammatory heterogeneous disease. Asthma inflammatory phenotypes based on blood eosinophil and neutrophil counts have never been identified and characterized in population-based studies.Methods: Adults with current asthma and available blood eosinophil and neutrophil counts from the French population-based CONSTANCES cohort were included. Current asthma was defined by reports of asthma attacks, symptoms or treatments in the last 12 months. Inflammatory phenotypes were based on low (L) and high (H) blood (B) eosinophil (E) (LBE/HBE
- Subjects :
- Male
Inflammation
Medicine (General)
Neutrophils
Neutrophil
General Medicine
Eosinophil
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
General Biochemistry, Genetics and Molecular Biology
Asthma
Eosinophils
Leukocyte Count
Phenotype
Blood
R5-920
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Humans
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Adults
Medicine
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology
[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology
Subjects
Details
- Language :
- English
- ISSN :
- 23523964
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- EBioMedicine
- Accession number :
- edsair.doi.dedup.....b255a5423a03e8e4881dd85d0223c3b7