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Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort

Authors :
Tajidine Tsiavia
Joseph Henny
Marcel Goldberg
Marie Zins
Nicolas Roche
Laurent Orsi
Rachel Nadif
Centre de recherche en épidémiologie et santé des populations (CESP)
Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay
Cohortes épidémiologiques en population (CONSTANCES)
Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité)
Université Paris Cité - UFR Médecine [Santé] (UPCité UFR Médecine)
Université Paris Cité (UPCité)
Hôpital Cochin [AP-HP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
ANR-11-INBS-0002
AstraZeneca
Meso Scale Diagnostics, MSD
Fondation pour la Recherche Médicale, FRM: ECO202006011654
H. Lundbeck A/S
Conservatoire National des Arts et Métiers, CNAM
The CONSTANCES cohort receives grants from ANR (ANR-11-INBS-0002), the Caisse nationale d'assurance maladie-CNAM and the Ministry of research. CONSTANCES also receives funding from MSD, AstraZeneca, Lundbeck and L'Oréal, managed by INSERM-Transfert. T.Tsiavia is supported by a PhD grant from the Fondation pour le Recherche Médicale (ECO202006011654).
T.Tsiavia, L.Orsi and R.Nadif have verified the underlying data, designed and conducted the study
J.Henny, M.Goldberg, M.Zins, L.Orsi and R.Nadif contributed to the data acquisition
T.Tsiavia, L.Orsi and R.Nadif interpreted the data
T.Tsiavia, L.Orsi and R.Nadif drafted the article
T.Tsiavia, J.Henny, M.Goldberg, M.Zins, N.Roche, L.Orsi and R.Nadif contributed to the critical review of important intellectual content
all authors edited and approved the final manuscript. The authors thank the ?Caisse nationale d'assurance maladie? (CNAM) and the ?Centres d'examens de sant?? of the French Social Security which are collecting a large part of the data, as well as the ?Caisse nationale d'assurance vieillesse?, ClinSearch, Asqualab and Eurocell in charge of the data quality control. The authors thank all those who participated to the setting of the study and on the various aspects of the examinations involved: interviewers, technicians for lung function testing, coders, those involved in quality control, data and sample management and all the staffs from the inclusion centers (HPCs). They are indebted to all the participating individuals without whom the study would not have been possible. The authors also thank S Le Got, S Lemonnier, A Ozguler, C Ribet from Inserm UMS11. The authors are also grateful to Groupe Respiratoire CONSTANCES: MC Delmas, O Dumas, V Giraud, Y Iwatsubo, B Leynaert, N Le Moual, T Perez, R Varraso. The CONSTANCES cohort receives grants from ANR (ANR-11-INBS-0002), the Caisse nationale d'assurance maladie-CNAM and the Ministry of research. CONSTANCES also receives funding from MSD, AstraZeneca, Lundbeck and L'Or?al, managed by INSERM-Transfert. T.Tsiavia is supported by a PhD grant from the Fondation pour le Recherche M?dicale (ECO202006011654). Access to sensitive and personal data, such as those from CONSTANCES cohort, is restricted by French law. The CONSTANCES coordination team makes the data available, upon request, to qualified researchers who have obtained prior authorization from the French national data protection authority (Commission de l'informatique et des libert?s, CNIL). Information for applicants to CONSTANCES data is available on the website: https://www.constances.fr/CFP.pdf. CONSTANCES investigators may be contacted at following address: contact@constances.fr
HAL UVSQ, Équipe
Source :
EBioMedicine, Vol 76, Iss, Pp 103875-(2022), EBioMedicine, EBioMedicine, 2022, 76, pp.103875. ⟨10.1016/j.ebiom.2022.103875⟩
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

International audience; Background: Asthma is an inflammatory heterogeneous disease. Asthma inflammatory phenotypes based on blood eosinophil and neutrophil counts have never been identified and characterized in population-based studies.Methods: Adults with current asthma and available blood eosinophil and neutrophil counts from the French population-based CONSTANCES cohort were included. Current asthma was defined by reports of asthma attacks, symptoms or treatments in the last 12 months. Inflammatory phenotypes were based on low (L) and high (H) blood (B) eosinophil (E) (LBE/HBE

Subjects

Subjects :
Male
Inflammation
Medicine (General)
Neutrophils
Neutrophil
General Medicine
Eosinophil
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
General Biochemistry, Genetics and Molecular Biology
Asthma
Eosinophils
Leukocyte Count
Phenotype
Blood
R5-920
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Humans
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Adults
Medicine
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology
[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology

Details

Language :
English
ISSN :
23523964
Volume :
76
Database :
OpenAIRE
Journal :
EBioMedicine
Accession number :
edsair.doi.dedup.....b255a5423a03e8e4881dd85d0223c3b7

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Authors Abstract Subjects Details