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The number of copies of an a-like region in the serotype-3 Marek's disease virus DNA genome is variable

Authors :
Robert F. Silva
J.David Reilly
Source :
Virology. 193(1)
Publication Year :
1993

Abstract

A 1.2-kilobasepair DNA region ( a -like) in the serotype-3 Marek's disease virus was directly repeated at the ends of the long (L) and short (S) components of the genome and repeated in the opposite orientation at the junction between the L and S components. Four variants from plaque-purified virus that vat led in the number of copies of the a-like region were identified. The predominant variant contained one copy at both ends of the genome and at the L-S junction, Two other variants contained either one or two copies at the L end and one to three copies at the L-S junction. The fourth variant lacked the a -like region at the L end and the L-S junction. The fourth variant became the predominate species as the virus was serially passaged in cell culture.

Details

ISSN :
00426822
Volume :
193
Issue :
1
Database :
OpenAIRE
Journal :
Virology
Accession number :
edsair.doi.dedup.....b274b67e9be1aee81724fc2e8f7efd14