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The number of copies of an a-like region in the serotype-3 Marek's disease virus DNA genome is variable
- Source :
- Virology. 193(1)
- Publication Year :
- 1993
-
Abstract
- A 1.2-kilobasepair DNA region ( a -like) in the serotype-3 Marek's disease virus was directly repeated at the ends of the long (L) and short (S) components of the genome and repeated in the opposite orientation at the junction between the L and S components. Four variants from plaque-purified virus that vat led in the number of copies of the a-like region were identified. The predominant variant contained one copy at both ends of the genome and at the L-S junction, Two other variants contained either one or two copies at the L end and one to three copies at the L-S junction. The fourth variant lacked the a -like region at the L end and the L-S junction. The fourth variant became the predominate species as the virus was serially passaged in cell culture.
- Subjects :
- Serotype
Genetics
Marek's disease
biology
Restriction Mapping
Chick Embryo
Fibroblasts
biology.organism_classification
Genome
Virology
Virus
Restriction fragment
chemistry.chemical_compound
chemistry
DNA, Viral
biology.protein
Animals
Repeated sequence
Herpesvirus 2, Gallid
DNA
Cells, Cultured
Gene Deletion
Genomic organization
Repetitive Sequences, Nucleic Acid
Subjects
Details
- ISSN :
- 00426822
- Volume :
- 193
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....b274b67e9be1aee81724fc2e8f7efd14