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Development and clinical validation of a robust knowledge‐based planning model for stereotactic body radiotherapy treatment of centrally located lung tumors
- Source :
- Journal of Applied Clinical Medical Physics
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- Purpose To develop a robust and adaptable knowledge‐based planning (KBP) model with commercially available RapidPlanTM for early stage, centrally located non‐small‐cell lung tumors (NSCLC) treated with stereotactic body radiotherapy (SBRT) and improve a patient's“simulation to treatment” time. Methods The KBP model was trained using 86 clinically treated high‐quality non‐coplanar volumetric modulated arc therapy (n‐VMAT) lung SBRT plans with delivered prescriptions of 50 or 55 Gy in 5 fractions. Another 20 independent clinical n‐VMAT plans were used for validation of the model. KBP and n‐VMAT plans were compared via Radiation Therapy Oncology Group (RTOG)–0813 protocol compliance criteria for conformity (CI), gradient index (GI), maximal dose 2 cm away from the target in any direction (D2cm), dose to organs‐at‐risk (OAR), treatment delivery efficiency, and accuracy. KBP plans were re‐optimized with larger calculation grid size (CGS) of 2.5 mm to assess feasibility of rapid adaptive re‐planning. Results Knowledge‐based plans were similar or better than n‐VMAT plans based on a range of target coverage and OAR metrics. Planning target volume (PTV) for validation cases was 30.5 ± 19.1 cc (range 7.0–71.7 cc). KBPs provided an average CI of 1.04 ± 0.04 (0.97–1.11) vs. n‐VMAT plan'saverage CI of 1.01 ± 0.04 (0.97–1.17) (P
- Subjects :
- Organs at Risk
Lung Neoplasms
Knowledge based planning
medicine.medical_treatment
Planning target volume
adaptive re‐planning
Radiosurgery
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
Medicine
Radiation Oncology Physics
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
Instrumentation
Retrospective Studies
Radiation
Lung
RapidPlan model
Mean lung dose
business.industry
Radiotherapy Planning, Computer-Assisted
Radiotherapy Dosage
knowledge‐based planning
Radiation therapy
centrally located lung SBRT
medicine.anatomical_structure
030220 oncology & carcinogenesis
Radiotherapy, Intensity-Modulated
Nuclear medicine
business
Stereotactic body radiotherapy
Quality assurance
Subjects
Details
- Language :
- English
- ISSN :
- 15269914
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Clinical Medical Physics
- Accession number :
- edsair.doi.dedup.....b28b4cabb2fadec96b24c91dd2fc93e4