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Use of healthcare claims to validate the Prevention of Arrhythmia Device Infection Trial cardiac implantable electronic device infection risk score
- Source :
- Ahmed, F Z, Blomström-Lundqvist, C, Bloom, H, Cooper, C, Ellis, C, Goette, A, Greenspon, A J, Love, C J, Johansen, J B, Philippon, F, Tarakji, K G, Holbrook, R, Sherfesee, L, Xia, Y, Seshadri, S, Lexcen, D R & Krahn, A D 2021, ' Use of healthcare claims to validate the Prevention of Arrhythmia Device Infection Trial cardiac implantable electronic device infection risk score ', Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 23, no. 9, pp. 1446-1455 . https://doi.org/10.1093/europace/euab028, Europace
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Aim The Prevention of Arrhythmia Device Infection Trial (PADIT) infection risk score, developed based on a large prospectively collected data set, identified five independent predictors of cardiac implantable electronic device (CIED) infection. We performed an independent validation of the risk score in a data set extracted from U.S. healthcare claims. Methods and results Retrospective identification of index CIED procedures among patients aged ≥18 years with at least one record of a CIED procedure between January 2011 and September 2014 in a U.S health claims database. PADIT risk factors and major CIED infections (with system removal, invasive procedure without system removal, or infection-attributable death) were identified through diagnosis and procedure codes. The data set was randomized by PADIT score into Data Set A (60%) and Data Set B (40%). A frailty model allowing multiple procedures per patient was fit using Data Set A, with PADIT score as the only predictor, excluding patients with prior CIED infection. A data set of 54 042 index procedures among 51 623 patients with 574 infections was extracted. Among patients with no history of prior CIED infection, a 1 unit increase in the PADIT score was associated with a relative 28% increase in infection risk. Prior CIED infection was associated with significant incremental predictive value (HR 5.66, P<br />Graphical Abstract
- Subjects :
- Adult
Pacemaker, Artificial
medicine.medical_specialty
Infection risk
Prosthesis-Related Infections
Adolescent
medicine.medical_treatment
Implantable cardioverter-defibrillator
Health claims on food labels
Risk Factors
Clinical Research
Pacing and Cardiac Resynchronization Therapy
Physiology (medical)
Internal medicine
Health care
medicine
Humans
AcademicSubjects/MED00200
Cardiac and Cardiovascular Systems
Retrospective Studies
Kardiologi
Framingham Risk Score
business.industry
Cardiac arrhythmia
Arrhythmias, Cardiac
Targeted interventions
Predictive value
Defibrillators, Implantable
Pacemaker
Risk score
Electronics
Infection
Cardiology and Cardiovascular Medicine
business
Delivery of Health Care
Subjects
Details
- ISSN :
- 15322092 and 10995129
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- EP Europace
- Accession number :
- edsair.doi.dedup.....b28d94d04fa78e889093d92989ae4ada