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SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021), Nature Communications
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8–4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7–100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI: 11.0–28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI: 17.2–36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression.<br />Vo’, Italy, is a unique setting for studying SARS-CoV-2 antibody dynamics because mass testing was conducted there early in the pandemic. Here, the authors perform two follow-up serological surveys and estimate seroprevalence, the extent of within-household transmission, and the impact of contact tracing.
- Subjects :
- 0301 basic medicine
Male
Veterinary medicine
Epidemiology
Science
Population
General Physics and Astronomy
Antibodies, Viral
Article
General Biochemistry, Genetics and Molecular Biology
Serology
03 medical and health sciences
0302 clinical medicine
COVID-19 Testing
Seroepidemiologic Studies
Credible interval
Seroprevalence
Medicine
Humans
Computational models
Serologic Tests
030212 general & internal medicine
education
Nucleocapsid
Author Correction
education.field_of_study
Multidisciplinary
biology
business.industry
SARS-CoV-2
COVID-19
General Chemistry
Confidence interval
030104 developmental biology
Immunoglobulin M
Italy
Viral infection
COVID-19 Nucleic Acid Testing
Immunoglobulin G
Spike Glycoprotein, Coronavirus
biology.protein
Female
Contact Tracing
Serostatus
business
Contact tracing
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....b2acc5cd95aaad9d3b688542e8c632ea