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Early liver transplantation is crucial in children with liver disease and pulmonary artery hypertension
- Source :
- Journal of Hepatology. 28:337-342
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Background/Aims: Early liver transplantation is crucial in children with liver disease and pulmonary artery hypertension. Some severe pulmonary vascular anomalies associated with portal hypertension disappear after isolated liver transplantation. Evolution of pulmonary artery hypertension due to plexogenic arteriopathy is controversial, as this association is still considered a contraindication to isolated liver transplantation. Outcome of pulmonary hypertension after isolated liver transplantation is reported in three patients with portal hypertension. Methods: After echocardiographic diagnosis, the patients had a complete hemodynamic exploration, and two had a lung biopsy. After liver transplantation, the survivors had echocardiographic follow up and a second hemodynamic exploration. Results: In two children, pulmonary pressures and resistances returned to near-normal values 1 and 6 years after successful isolated liver transplantation. The third patient, with the most severe arteriopathy, had to wait 1 year for a donor, and the attempted transplantation was complicated by ventricular tachycardia; death occurred 2 days after surgery. Conclusions: Liver transplantation can reverse pulmonary artery hypertension due to high pulmonary resistances complicating liver disease with portal hypertension, provided it is carried out at an early stage. Early detection of pulmonary hypertension by systematic echocardiography may thus be crucial in these children with portal hypertension.
- Subjects :
- medicine.medical_specialty
Time Factors
Adolescent
Hypertension, Pulmonary
medicine.medical_treatment
Liver transplantation
Liver disease
Biliary Atresia
medicine.artery
Hypertension, Portal
medicine
Humans
Child
Hepatology
business.industry
Vascular disease
Liver Diseases
Respiratory disease
Hemodynamics
medicine.disease
Pulmonary hypertension
Liver Transplantation
Surgery
Transplantation
Echocardiography
Pulmonary artery
Portal hypertension
Female
business
Subjects
Details
- ISSN :
- 01688278
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Hepatology
- Accession number :
- edsair.doi.dedup.....b2ad0d871ed725e1b5bc4e20d8fa3828
- Full Text :
- https://doi.org/10.1016/0168-8278(88)80022-9