Pathologic Complete Response After Chemoradiation of a Massive Primary Urethral Carcinoma

Purpose To describe a notable response to chemoradiation in a patient with locally advanced squamous cell cancer of the urethra. Materials and Methods Records reviewed of 60-year-old man with 15.3cm squamous cell cancer of the urethra. Treatment response assessed radiographically and pathologically, and post-treatment clinical status determined. Results Patient received 73.8 Gy plus concurrent cisplatin and 5-FU, followed by consolidative surgery. Patient had pathological complete response and remains radiographically disease-free at 28 months. Conclusion Consolidative surgery may be unnecessary even for large squamous cell carcinomas of the urethra following chemoradiation.