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Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex
- Source :
- Proceedings of the National Academy of Sciences. 109:13046-13051
- Publication Year :
- 2012
- Publisher :
- Proceedings of the National Academy of Sciences, 2012.
-
Abstract
- The evolution of cadherins, which are essential for metazoan multicellularity and restricted to metazoans and their closest relatives, has special relevance for understanding metazoan origins. To reconstruct the ancestry and evolution of cadherin gene families, we analyzed the genomes of the choanoflagellate Salpingoeca rosetta , the unicellular outgroup of choanoflagellates and metazoans Capsaspora owczarzaki , and a draft genome assembly from the homoscleromorph sponge Oscarella carmela . Our finding of a cadherin gene in C. owczarzaki reveals that cadherins predate the divergence of the C. owczarzaki , choanoflagellate, and metazoan lineages. Data from these analyses also suggest that the last common ancestor of metazoans and choanoflagellates contained representatives of at least three cadherin families, lefftyrin, coherin, and hedgling. Additionally, we find that an O. carmela classical cadherin has predicted structural features that, in bilaterian classical cadherins, facilitate binding to the cytoplasmic protein β-catenin and, thereby, promote cadherin-mediated cell adhesion. In contrast with premetazoan cadherin families (i.e., those conserved between choanoflagellates and metazoans), the later appearance of classical cadherins coincides with metazoan origins.
- Subjects :
- Most recent common ancestor
animal structures
Capsaspora
Molecular Sequence Data
Evolution, Molecular
Phylogenetics
Animals
Gene family
Choanoflagellate
Choanoflagellata
Phylogeny
beta Catenin
DNA Primers
Genetics
Genomic Library
Genome
Multidisciplinary
Base Sequence
biology
Cadherin
Computational Biology
Genetic Variation
Sequence Analysis, DNA
Biological Sciences
Cadherins
biology.organism_classification
Multicellular organism
Catenin complex
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....b2c22dad8dc10941c0d6aef29c9cc147