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Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging
- Source :
- Thaler, C, Kyselyova, A A, Faizy, T D, Nawka, M T, Jespersen, S, Hansen, B, Stellmann, J-P, Heesen, C, Stürner, K H, Stark, M, Fiehler, J, Bester, M & Gellißen, S 2021, ' Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging ', PLOS ONE, vol. 16, no. 2, e0245844 . https://doi.org/10.1371/journal.pone.0245844, PLoS ONE, PLoS ONE, 2021, 16 (2), pp.e0245844. ⟨10.1371/journal.pone.0245844⟩, PLoS ONE, Vol 16, Iss 2, p e0245844 (2021), PLoS ONE, Public Library of Science, 2021, 16 (2), pp.e0245844. ⟨10.1371/journal.pone.0245844⟩
- Publication Year :
- 2021
-
Abstract
- Background Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders. Methods Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH). Results Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10−3mm2/sec), followed by NAWM (0.808 ± 0.163 10−3mm2/sec), CE-L (0.853 ± 0.211 10−3mm2/sec), BH (0.957 ± 0.304 10−3mm2/sec) and FLAIR-L (0.976 ± 0.35 10−3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not. Conclusion MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.
- Subjects :
- Central Nervous System
Male
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Astronomical Sciences
Fluid-attenuated inversion recovery
Nervous System
Diagnostic Radiology
030218 nuclear medicine & medical imaging
Cohort Studies
Medical Conditions
0302 clinical medicine
Nuclear magnetic resonance
Materials Physics
Medicine and Health Sciences
Image Processing, Computer-Assisted
Microstructure
Diffusion Kurtosis Imaging
Brain Mapping
Multidisciplinary
medicine.diagnostic_test
Chemistry
Radiology and Imaging
Physics
Neurodegenerative Diseases
Middle Aged
Celestial Objects
Magnetic Resonance Imaging
White Matter
Diffusion Tensor Imaging
medicine.anatomical_structure
Neurology
Physical Sciences
Kurtosis
Medicine
Female
Anatomy
medicine.symptom
Research Article
Adult
Multiple Sclerosis
Black Holes
Adolescent
Imaging Techniques
Brain Morphometry
Science
Immunology
Materials Science
Neuroimaging
Research and Analysis Methods
Autoimmune Diseases
Lesion
White matter
Young Adult
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
medicine
Humans
Multiple sclerosis
Biology and Life Sciences
Magnetic resonance imaging
medicine.disease
Demyelinating Disorders
Lesions
Clinical Immunology
Clinical Medicine
030217 neurology & neurosurgery
Neuroscience
Diffusion MRI
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Thaler, C, Kyselyova, A A, Faizy, T D, Nawka, M T, Jespersen, S, Hansen, B, Stellmann, J-P, Heesen, C, Stürner, K H, Stark, M, Fiehler, J, Bester, M & Gellißen, S 2021, ' Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging ', PLOS ONE, vol. 16, no. 2, e0245844 . https://doi.org/10.1371/journal.pone.0245844, PLoS ONE, PLoS ONE, 2021, 16 (2), pp.e0245844. ⟨10.1371/journal.pone.0245844⟩, PLoS ONE, Vol 16, Iss 2, p e0245844 (2021), PLoS ONE, Public Library of Science, 2021, 16 (2), pp.e0245844. ⟨10.1371/journal.pone.0245844⟩
- Accession number :
- edsair.doi.dedup.....b2ccd72f2eafd2b2ebc298c559c3dd18