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Novel Locus Required for Expression of High-Level Macrolide-Lincosamide-Streptogramin B Resistance in Staphylococcus aureus

Authors :
Patrick K. Martin
Y. Bao
Laura McDowell
E. Boyer
Molly B. Schmid
Kelly M. Winterberg
Jerry M. Buysse
Publication Year :
2002
Publisher :
American Society for Microbiology, 2002.

Abstract

The yycF1 (Ts) mutation in Staphylococcus aureus conferred hypersensitivity to macrolide-lincosamide-streptogramin B (MLS B ) antibiotics on strains either containing or lacking ermB . The overexpression of the S. aureus Ssa protein restored the yycF1 mutant to wild-type levels of susceptibility. Inactivation of ssa in an unmutagenized strain dramatically reduced ermB -based resistance. Conditional loss of function or expression of ssa in the yycF1 mutant is proposed to result in the observed hypersensitivity to MLS B antibiotics.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....b2e70b48811a2f2d2f6ebc7dbafdf55d