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Th2-like immune response in radiation-induced lung fibrosis
- Source :
- Oncology Reports.
- Publication Year :
- 2011
- Publisher :
- Spandidos Publications, 2011.
-
Abstract
- Pulmonary fibrosis is a common delayed side effect of radiation therapy. Since its mechanism is almost unknown, little can be done to prevent or treat it. Th2 cytokines have been clearly implicated as mediators of asthma, and evidence is mounting that type 2 immune responses may also promote the development of pulmonary fibrosis. The aim of this study was to investigate whether Th2-like immune responses account for the development and progression of chronic radiation pulmonary fibrosis. C57BL/6 mice received thoracic irradiation of 12 Gy and were sacrificed at 1 h and 1, 2, 4, 8, 16 and 24 weeks post-irradiation (p.i.). We assayed the expression of IL-13 in serum, and the expression of hydroxyproline and the mRNA and protein of GATA-3 and Arg-1 in lung tissue. mRNA and protein analysis revealed the expression of these Th2-immune response-associated factors (GATA-3, IL-13 and Arg-1) in mice after irradiation. Without causing conspicuous fibrotic pathological changes at the early post-irradiation phase (1 and 2 weeks p.i.), a Th2 profile was confirmed by significantly elevated expression of Th2-specific transcription factor GATA-3 mRNA (P
- Subjects :
- Cancer Research
medicine.medical_specialty
Side effect
Pulmonary Fibrosis
medicine.medical_treatment
Biology
Mice
Hydroxyproline
chemistry.chemical_compound
Th2 Cells
Immune system
Internal medicine
Pulmonary fibrosis
medicine
Animals
Lung
Respiratory disease
Dose-Response Relationship, Radiation
General Medicine
medicine.disease
Immunohistochemistry
Mice, Inbred C57BL
Radiation Pneumonitis
Endocrinology
Cytokine
Oncology
chemistry
Apoptosis
Models, Animal
Interleukin 13
Female
Subjects
Details
- ISSN :
- 17912431 and 1021335X
- Database :
- OpenAIRE
- Journal :
- Oncology Reports
- Accession number :
- edsair.doi.dedup.....b2e9499a926ab6a4b939181b6c1b2b31