Back to Search
Start Over
CLINE: a web-tool for the comparison of biological dendrogram structures
- Source :
- BMC Bioinformatics, BMC Bioinformatics, Vol 20, Iss 1, Pp 1-12 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background When visually comparing the results of hierarchical clustering, the differences in the arrangements of components are of special interest. However, in a biological setting, identifying such differences becomes less straightforward, as the changes in the dendrogram structure caused by permuting biological replicates, do not necessarily imply a different biological interpretation. Here, we introduce a visualization tool to help identify biologically similar topologies across different clustering results, even in the presence of replicates. Results Here we introduce CLINE, an open-access web application that allows users to visualize and compare multiple dendrogram structures, by visually displaying the links between areas of similarity across multiple structures. Through the use of a single page and a simple user interface, the user is able to load and remove structures form the visualization, change some aspects of their display and set the parameters used to match cluster topology across consecutive pairs of dendrograms. Conclusions We have implemented a web-tool that allows the users to visualize different dendrogram structures, showing not only the structures themselves, but also linking areas of similarity across multiple structures. The software is freely available at http://mizuguchilab.org/tools/cline/. Also, the source code, documentation and installation instructions are available on GitHub at https://github.com/RodolfoAllendes/cline/.
- Subjects :
- 0106 biological sciences
Computer science
lcsh:Computer applications to medicine. Medical informatics
computer.software_genre
010603 evolutionary biology
01 natural sciences
Biochemistry
Clustering
Set (abstract data type)
03 medical and health sciences
Similarity (network science)
Structural Biology
Cluster Analysis
Cline (hydrology)
Cluster analysis
lcsh:QH301-705.5
Molecular Biology
Visualization
030304 developmental biology
0303 health sciences
Dendrograms
Applied Mathematics
Dendrogram
Computer Science Applications
Hierarchical clustering
lcsh:Biology (General)
lcsh:R858-859.7
Data mining
computer
Software
Subjects
Details
- ISSN :
- 14712105
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Bioinformatics
- Accession number :
- edsair.doi.dedup.....b2f164d7cbf310fdf2d334d17125c4c3