Developing an In Vitro to In Vivo Extrapolation (IVIVE) Model to Predict Human Milk-to-Plasma Drug Concentration Ratios

Authors :: Hong Yang
Ivy Xue
Qimei Gu
Peng Zou
Tao Zhang
Yanhui Lu
Jeffery Fisher
Doanh Tran
Source :: Molecular Pharmaceutics. 19:2506-2517
Publication Year :: 2022
Publisher :: American Chemical Society (ACS), 2022.
Abstract: Determining the amount of drug transferred into human milk is critical for benefit-risk analysis of taking medication while breastfeeding. In this study, we developed an in vitro and in vivo extrapolation (IVIVE) model to predict human milk/plasma (

Subjects :: Milk, Human
Drug Discovery
ATP Binding Cassette Transporter, Subfamily G, Member 2
Humans
Pharmaceutical Science
Molecular Medicine
Biological Transport
Caco-2 Cells
Models, Biological
Neoplasm Proteins

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