Back to Search
Start Over
Impact of 18F-fluorodeoxyglucose PET/CT in the management of patients with plasma cell disorders
- Source :
- Nuclear Medicine Communications. 41:34-39
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- OBJECTIVES To evaluate the impact of F-fluorodeoxyglucose PET/CT examinations on the management of patients with plasma cell disorders. METHODS This is a retrospective review of patients in a provincial database with PET/CT performed for plasma cell disorders between 2011 and 2018. The impact of PET/CT on actual patient management and outcome was assessed by two independent readers who compared planned pre-PET/CT management, documented at time of PET/CT requisition, to actual management received through linkages to administrative databases. PET/CT was considered of high impact if it altered the provision of active treatment, changed the modality of treatment or chemotherapy regimen. Change in management and the proportion of patients with high impact PET/CT were assessed. RESULTS There were 44 patients with plasma cell disorders, including multiple myeloma, solitary plasmacytoma, Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes syndrome, or monoclonal gammopathy of undetermined significance or biclonal gammopathy of undetermined significance. Management was altered after 38/56 (67.9%) PET/CT scans. Considering just the initial PET/CT scan in patients who underwent multiple scans, 31/44 (70.5%) patients had their management altered subsequent to PET/CT. CONCLUSION PET/CT resulted in a change in planned management in more than two-thirds of patients with plasma cell disorders in the current selected patient cohort. These results should be validated in a larger prospective trial.
- Subjects :
- Male
medicine.medical_specialty
Plasma Cells
Plasma cell
Organomegaly
030218 nuclear medicine & medical imaging
Fluorodeoxyglucose PET
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
Multiple myeloma
Retrospective Studies
business.industry
General Medicine
Middle Aged
medicine.disease
Chemotherapy regimen
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
Female
Radiology
medicine.symptom
business
Polyneuropathy
Monoclonal gammopathy of undetermined significance
Subjects
Details
- ISSN :
- 01433636
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine Communications
- Accession number :
- edsair.doi.dedup.....b325582c672006c2b364a361169b4eb7