Regulation of parathyroid hormone secretion by adenyl cyclase

Authors :: Minoru Abe
Louis M. Sherwood
Source :: Biochemical and Biophysical Research Communications. 48:396-401
Publication Year :: 1972
Publisher :: Elsevier BV, 1972.
Abstract: Summary In a well-studied physiologically functioning in vitro system for the study of parathyroid hormone (PTH) secretion, both theophylline and dibutyryl cyclic adenosine monophate (dAMP) caused significant stimulation of PTH secretion. The quantity of PTH in the medium paralleled the release of cyclic 3′, 5′-AMP (CAMP) from incubated tissues. These studies suggest strongly that adenyl cyclase is the mediator of the known effects of calcium ion on PTH secretion.