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The Role of the Bone Marrow Microenvironment in the Pathophysiology of Myeloma and Its Significance in the Development of More Effective Therapies
- Source :
- Hematology/Oncology Clinics of North America. 21:1007-1034
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Multiple myeloma (MM) is viewed as a prototypic disease state for the study of how neoplastic cells interact with their local bone marrow (BM) microenvironment. This interaction reflects not only the osteo-tropic clinical behavior of MM and the clinical impact of the lytic bone lesions caused by its tumor cells but also underlines the broadly accepted notion that nonneoplastic cells of the BM can attenuate the activity of cytotoxic chemotherapy and glucocorticoids. This article summarizes the recent progress in characterization, at the molecular and cellular levels, of how the BM milieu interacts with MM cells and modifies their biologic behavior.
- Subjects :
- medicine.medical_specialty
Pathology
Hematology
business.industry
Osteoclasts
Cancer
Cell Communication
Disease
medicine.disease
Pathophysiology
medicine.anatomical_structure
Oncology
Lytic cycle
Bone Marrow
Internal medicine
Immunopathology
Humans
Medicine
Bone marrow
Stromal Cells
Multiple Myeloma
business
Multiple myeloma
Subjects
Details
- ISSN :
- 08898588
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Hematology/Oncology Clinics of North America
- Accession number :
- edsair.doi.dedup.....b368f2e0246d2ad3864e8cb3a547ea30