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Myelosuppressive Effect of Colaspase (L-Asparaginase) in Initial Treatment of Acute Lymphoblastic Leukaemia
- Publication Year :
- 1974
-
Abstract
- Analysis of the remission induction phase in three Medical Research Council trials of treatment of acute lymphoblastic leukaemia has provided evidence of the adverse effect of the combination of colaspase (L-asparaginase) with vincristine and prednisolone. Significant myelosuppression, particularly of the granulocytic series, resulted in an increase in Gram-negative sepsis and death during the neutropenic phase induced by colaspase. The rate of blast-cell regression was increased by colaspase. It is suggested that the introduction of colaspase should be delayed until there is evidence of bone marrow regeneration in order to procure this benefit without the attendant toxicity.
- Subjects :
- Oncology
Blood Platelets
Asparaginase
Vincristine
medicine.medical_specialty
Neutrophils
Prednisolone
Remission, Spontaneous
Spontaneous remission
Sepsis
chemistry.chemical_compound
Bone Marrow
Internal medicine
medicine
Leukocytes
Humans
Regeneration
Adverse effect
General Environmental Science
Clinical Trials as Topic
business.industry
General Engineering
General Medicine
Papers and Originals
medicine.disease
United Kingdom
Blood Cell Count
Leukemia, Lymphoid
medicine.anatomical_structure
chemistry
Toxicity
Immunology
General Earth and Planetary Sciences
Drug Therapy, Combination
Bone marrow
business
Ireland
medicine.drug
Agranulocytosis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b37d36d9e8da34020f5425ee72a47ce3