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A metal-based tumour necrosis factor-alpha converting enzyme inhibitor
- Source :
- Chemical Communications. 51:3973-3976
- Publication Year :
- 2015
- Publisher :
- Royal Society of Chemistry (RSC), 2015.
-
Abstract
- We report herein a novel iridium(III) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
- Subjects :
- Necrosis
p38 mitogen-activated protein kinases
ADAM17 Protein
Iridium
p38 Mitogen-Activated Protein Kinases
Monocytes
Catalysis
Cell Line
Organometallic Compounds
Materials Chemistry
medicine
Humans
Protease Inhibitors
Secretion
Phosphorylation
biology
Tumor Necrosis Factor-alpha
Chemistry
Metals and Alloys
General Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
ADAM Proteins
Biochemistry
Cell culture
Enzyme inhibitor
Ceramics and Composites
Cancer research
biology.protein
Tumor necrosis factor alpha
medicine.symptom
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....b3b96f52ca01152f26c3149fea4bcb03