Back to Search
Start Over
Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis
- Source :
- Chinese Medical Journal, Vol 132, Iss 24, Pp 2899-2904 (2019), Chinese Medical Journal
- Publication Year :
- 2019
- Publisher :
- Wolters Kluwer, 2019.
-
Abstract
- Supplemental Digital Content is available in the text<br />Background: Clinical outcomes of undifferentiated arthritis (UA) are diverse, and only 40% of patients with UA develop rheumatoid arthritis (RA) after 3 years. Discovering predictive markers at disease onset for further intervention is critical. Therefore, our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA development. Methods: We performed a prospective, multi-center study from January 2013 to October 2016 among Chinese patients diagnosed with UA in 22 tertiary-care hospitals. Clinical and serological parameters were obtained at recruitment. Follow-up was undertaken in all patients every 12 weeks for 2 years. Predictive factors of disease progression were identified using multivariate Cox proportional hazards regression. Results: A total of 234 patients were recruited in this study, and 17 (7.3%) patients failed to follow up during the study. Among the 217 patients who completed the study, 83 (38.2%) patients went into remission. UA patients who developed RA had a higher rheumatoid factor (RF)-positivity (42.9% vs. 16.8%, χ2 = 8.228, P = 0.008), anti-cyclic citrullinated peptide (CCP) antibody-positivity (66.7% vs. 10.7%, χ2 = 43.897, P
- Subjects :
- Adult
Male
medicine.medical_specialty
Arthritis
lcsh:Medicine
Anti-cyclic citrullinated peptide antibody
Peptides, Cyclic
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Rheumatoid factor
Humans
Prospective Studies
Prospective cohort study
Autoantibodies
Proportional Hazards Models
biology
Proportional hazards model
business.industry
Hazard ratio
lcsh:R
Undifferentiated arthritis
General Medicine
Original Articles
Middle Aged
medicine.disease
Confidence interval
030220 oncology & carcinogenesis
Rheumatoid arthritis
biology.protein
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Female
Antibody
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 25425641 and 03666999
- Volume :
- 132
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- Chinese Medical Journal
- Accession number :
- edsair.doi.dedup.....b3ce91f5e63abbc52026de4f0c72e14c