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Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer

Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer

Authors :
Antonella Daniele
Antonio Mazzocca
Angelo Paradiso
Carlo SabbĂ 
Rosa Divella
Source :
International Journal of Biological Sciences
Publication Year :
2019
Publisher :
Ivyspring International Publisher, 2019.

Abstract

Western populations are becoming increasingly sedentary and the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing and becoming one of the most common causes of liver disease worldwide. Also, NAFLD is considered one the new emerging risk factors for development of tumors of the gastro-intestinal tract, particularly hepatocellular carcinoma (HCC). Visceral obesity is an important risk factor for the onset of NAFLD. An accumulation of ectopic fat, including visceral obesity and fatty liver leads to a dysfunction of the adipose tissue with impaired production of adipocytokines which, in turn, favor an increase in pro-inflammatory cytokines. In this review, we discuss how the obesity-related chronic state of low-grade inflammation and the presence of NAFLD lead to the emergence of a microenvironment favorable to the development of cancer.

Details

Language :
English
ISSN :
14492288
Volume :
15
Issue :
3
Database :
OpenAIRE
Journal :
International Journal of Biological Sciences
Accession number :
edsair.doi.dedup.....b3d0c5ff0631de43910147ffc9804404