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Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer
Obesity, Nonalcoholic Fatty Liver Disease and Adipocytokines Network in Promotion of Cancer
- Source :
- International Journal of Biological Sciences
- Publication Year :
- 2019
- Publisher :
- Ivyspring International Publisher, 2019.
-
Abstract
- Western populations are becoming increasingly sedentary and the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing and becoming one of the most common causes of liver disease worldwide. Also, NAFLD is considered one the new emerging risk factors for development of tumors of the gastro-intestinal tract, particularly hepatocellular carcinoma (HCC). Visceral obesity is an important risk factor for the onset of NAFLD. An accumulation of ectopic fat, including visceral obesity and fatty liver leads to a dysfunction of the adipose tissue with impaired production of adipocytokines which, in turn, favor an increase in pro-inflammatory cytokines. In this review, we discuss how the obesity-related chronic state of low-grade inflammation and the presence of NAFLD lead to the emergence of a microenvironment favorable to the development of cancer.
- Subjects :
- obesity
Adipose tissue
Adipokine
Review
Bioinformatics
Applied Microbiology and Biotechnology
03 medical and health sciences
Liver disease
Adipokines
Non-alcoholic Fatty Liver Disease
NAFLD
Neoplasms
Nonalcoholic fatty liver disease
medicine
cancer
Animals
Humans
Risk factor
Molecular Biology
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
0303 health sciences
business.industry
Fatty liver
Cancer
Cell Biology
medicine.disease
Obesity
digestive system diseases
inflammation
adipocytokines
business
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14492288
- Volume :
- 15
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....b3d0c5ff0631de43910147ffc9804404