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A New Approach to Oxidative Stress and Inflammatory Signaling during Labour in Healthy Mothers and Neonates
- Source :
- Oxidative Medicine and Cellular Longevity, Oxidative Medicine and Cellular Longevity, Vol 2015 (2015)
- Publication Year :
- 2015
- Publisher :
- Hindawi Publishing Corporation, 2015.
-
Abstract
- The objective of the current study was to investigate for the first time and simultaneously the oxidative stress and inflammatory signaling induced during the delivery in healthy mothers and their neonates. 56 mothers with normal gestational course and spontaneous delivery were selected. Blood samples were taken from mother (before and after delivery) both from vein and artery of umbilical cord. Lower antioxidant enzymes activities were observed in neonates compared with their mothers and lower oxidative stress in umbilical cord artery with respect to vein. There was an overexpression of inflammatory cytokines in the mother, such as IL-6 and TNF-α, and, in addition, PGE2was also increased. Neonates showed lower levels of IL-6 and TNF-αand higher values of sTNF-RII and PGE2in comparison with their mothers. Parturition increases oxidative damage in the mother, although the indicators of oxidative damage were lower in umbilical cord artery with respect to umbilical vein. The overexpression of inflammatory cytokines reveals that fetus suffers its own inflammatory process during parturition.
- Subjects :
- Trabajo de parto
Aging
Glutatión peroxidasa
Physiology
Edad gestacional
medicine.disease_cause
Biochemistry
Umbilical cord
Umbilical vein
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha [Medical Subject Headings]
Named Groups::Persons::Parents::Mothers [Medical Subject Headings]
Pregnancy
Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings]
Catalasa
Labor, Obstetric
lcsh:Cytology
Femenino
Estrés oxidativo
General Medicine
Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Superoxide Dismutase [Medical Subject Headings]
Catalase
Fetal Blood
Sangre fetal
Superóxido dismutasa
Humanos
Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Glutathione Peroxidase [Medical Subject Headings]
medicine.anatomical_structure
Gestation
Female
Artery
Signal Transduction
Research Article
Adult
Article Subject
Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy::Labor, Obstetric [Medical Subject Headings]
Mothers
Gestational Age
Dinoprostona
Named Groups::Persons::Age Groups::Infant::Infant, Newborn [Medical Subject Headings]
Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6 [Medical Subject Headings]
Chemicals and Drugs::Biological Factors::Inflammation Mediators::Autacoids::Eicosanoids::Prostaglandins::Prostaglandins E::Dinoprostone [Medical Subject Headings]
Dinoprostone
Interleucina-6
Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Gestational Age [Medical Subject Headings]
Proinflammatory cytokine
Anatomy::Fluids and Secretions::Body Fluids::Blood::Fetal Blood [Medical Subject Headings]
Recién nacido
medicine
Humans
lcsh:QH573-671
Fetus
Glutathione Peroxidase
business.industry
Interleukin-6
Superoxide Dismutase
Tumor Necrosis Factor-alpha
Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction [Medical Subject Headings]
Infant, Newborn
Cell Biology
medicine.disease
Factor de necrosis tumoral alfa
Oxidative Stress
Check Tags::Female [Medical Subject Headings]
Transducción de señal
Immunology
Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Catalase [Medical Subject Headings]
Madres
business
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 19420900
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....b3d3cb81b33c79bf0524d4fd1bb10591
- Full Text :
- https://doi.org/10.1155/2015/178536