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Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis
- Source :
- Mechanisms of Development. 109(2):413-417
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- The human RUNX3/AML2 gene belongs to the ‘runt domain’ family of transcription factors that act as gene expression regulators in major developmental pathways. Here, we describe the expression pattern of Runx3 during mouse embryogenesis compared to the expression pattern of Runx1. E10.5 and E14.5–E16.5 embryos were analyzed using both immunohistochemistry and β-galactosidase activity of targeted Runx3 and Runx1 loci. We found that Runx3 expression overlapped with that of Runx1 in the hematopoietic system, whereas in sensory ganglia, epidermal appendages, and developing skeletal elements, their expression was confined to different compartments. These data provide new insights into the function of Runx3 and Runx1 in organogenesis and support the possibility that cross-regulation between them plays a role in embryogenesis.
- Subjects :
- Embryology
Time Factors
Hematopoietic System
Organogenesis
Biology
Bone and Bones
chemistry.chemical_compound
Mice
hemic and lymphatic diseases
Proto-Oncogene Proteins
Gene expression
Animals
Tissue Distribution
Gene
Transcription factor
Genetics
Bone Development
Embryogenesis
Embryo
Immunohistochemistry
digestive system diseases
Cell biology
Neoplasm Proteins
DNA-Binding Proteins
RUNX1
chemistry
embryonic structures
Core Binding Factor Alpha 2 Subunit
Function (biology)
Transcription Factors
Developmental Biology
Subjects
Details
- ISSN :
- 09254773
- Volume :
- 109
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Mechanisms of Development
- Accession number :
- edsair.doi.dedup.....b3d44d56b7e83bfa25faa74b6936d676
- Full Text :
- https://doi.org/10.1016/s0925-4773(01)00537-8