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Pilot study of DNA methylation-derived neutrophil-to-lymphocyte ratio and survival in pediatric medulloblastoma

Authors :
Vidal M. Arroyo
Murali Chintagumpala
M. Fatih Okcu
Philip J. Lupo
Surya P. Rednam
Austin L. Brown
Michael E. Scheurer
Jeffrey C. Murray
Source :
Cancer Epidemiology. 59:71-74
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

Introduction Methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) has been identified as a potential prognostic biomarker of outcomes in various cancers. We evaluated the prognostic value of blood-derived mdNLR within a retrospective cohort of pediatric medulloblastoma patients. Materials and methods DNA methylation was measured in archival peripheral blood samples collected on 56 pediatric medulloblastoma patients. Hazard ratios (HR) and 95% confidence intervals (CI) for the association between mdNLR and survival were evaluated using Cox proportional hazard models. Results Compared to patients who were alive at last follow-up (n = 43), the mean mdNLR value was slightly higher in deceased patients (n = 13) (12.3 vs. 5.2,P = 0.163). Elevated log-transformed mdNLR was suggestively associated with an increased likelihood of death in unadjusted models (HR=1.43, 95%CI: 0.92–2.22) and significantly associated with mortality in adjusted models (HR=1.61, 95%CI: 1.01–2.58). Discussion Future work is warranted to investigate the relationship between mdNLR outcomes in specific pediatric medulloblastoma molecular subgroups.

Details

ISSN :
18777821
Volume :
59
Database :
OpenAIRE
Journal :
Cancer Epidemiology
Accession number :
edsair.doi.dedup.....b3d80f48874b2af95f667e79f9cba832