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Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
- Source :
- International Immunology. 11:81-88
- Publication Year :
- 1999
- Publisher :
- Oxford University Press (OUP), 1999.
-
Abstract
- Helper T cells are classified into Th1 and Th2 subsets based on their profiles of cytokine production. Th1 cells are involved in cell-mediated immunity, whereas Th2 cells induce humoral responses. Selective recruitment of these two subsets depends on specific adhesion molecules and specific chemoattractants. Here, we demonstrate that the T cell-directed CC chemokine thymus and activation-regulated chemokine (TARC) was abundantly produced by monocytes treated with granulocyte macrophage colony stimulating factor (GM-CSF) or IL-3, especially in the presence of IL-4 and by dendritic cells derived from monocytes cultured with GM-CSF + IL-4. The receptor for TARC and another macrophage/dendritic cell-derived CC chemokine macrophage-derived chemokine (MDC) is CCR4, a G protein-coupled receptor. CCR4 was found to be expressed on approximately 20% of adult peripheral blood effector/memory CD4+ T cells. T cells attracted by TARC and MDC generated cell lines predominantly producing Th2-type cytokines, IL-4 and IL-5. Fractionated CCR4+ cells but not CCR4- cells also selectively gave rise to Th2-type cell lines. When naive CD4+ T cells from adult peripheral blood were polarized in vitro, Th2-type cells selectively expressed CCR4 and vigorously migrated toward TARC and MDC. Taken together, CCR4 is selectively expressed on Th2-type T cells and antigen-presenting cells may recruit Th2 cells expressing CCR4 by producing TARC and MDC in Th2-dominant conditions.
- Subjects :
- Antigens, Differentiation, T-Lymphocyte
CD4-Positive T-Lymphocytes
Receptors, CCR4
Chemokine receptor CCR5
Immunology
Antigen-Presenting Cells
Thymus Gland
C-C chemokine receptor type 6
Monocytes
CCL5
Th2 Cells
T-Lymphocyte Subsets
Humans
Immunology and Allergy
CCL17
CXCL10
CXCL16
Chemokine CCL22
biology
Chemistry
Macrophages
Granulocyte-Macrophage Colony-Stimulating Factor
Dendritic Cells
General Medicine
Cell biology
Chemotaxis, Leukocyte
Chemokines, CC
biology.protein
Leukocyte Common Antigens
XCL2
Interleukin-3
Receptors, Chemokine
Chemokine CCL17
Interleukin-4
Chemokines
CC chemokine receptors
Immunologic Memory
Subjects
Details
- ISSN :
- 14602377 and 09538178
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- International Immunology
- Accession number :
- edsair.doi.dedup.....b3e03d0d78dc49f81194f70f95e49450