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Fibrin lysability is associated with central obesity and inflammation in women with polycystic ovary syndrome
- Source :
- Godtfredsen, A C M, Sidelmann, J J, Gram, J B, Skovsager Andersen, M & Glintborg, D 2020, ' Fibrin lysability is associated with central obesity and inflammation in women with polycystic ovary syndrome ', Acta Obstetricia et Gynecologica Scandinavica, vol. 99, no. 8, pp. 1078-1084 . https://doi.org/10.1111/aogs.13825
- Publication Year :
- 2020
-
Abstract
- INTRODUCTION: Polycystic ovary syndrome (PCOS) is characterized by increased central fat mass (CFM), hyper-inflammation, and hemostatic alterations; the risk of cardiovascular disease may also be increased. Reduced fibrin lysability is a risk factor for cardiovascular disease. The present study assessed fibrin lysability in women with PCOS and controls of similar age and body mass index.MATERIAL AND METHODS: Ninety women with PCOS and 35 controls of comparable age and body mass index were included. Hemostatic markers (fibrin lysability, fibrinogen, coagulation factor XIII, plasminogen, plasminogen activator inhibitor 1 [PAI-1], plasmin inhibitor, thrombin activatable fibrinolysis inhibitor (TAFI), D-dimer), C-reactive protein (CRP), body mass index, waist-to-hip ratio, CFM determined by Dual-energy X-ray absorptiometry scan, and sex hormones (testosterone estradiol, and sex hormone binding globulin) were determined.RESULTS: TAFI and CRP were higher in women with PCOS, than controls. In women with PCOS, fibrin lysability correlated with CFM, waist-to-hip ratio, CRP, fibrinogen, and all hemostatic variables (P ≤ .004) except TAFI and D-dimer. CFM correlated with fibrinogen, CRP, coagulation factor XIII, waist-to-hip ratio, plasminogen, PAI-1, plasmin inhibitor, and TAFI (P < .02). In controls, fibrin lysability correlated with CFM, fibrinogen, coagulation factor XIII, and plasmin inhibitor (P ≤ .02). CFM correlated with PAI-1, plasmin inhibitor, coagulation factor XIII, fibrinogen, and CRP (P ≤ .05). Stepwise regression analysis revealed that fibrin lysability was associated with CFM, fibrinogen and CRP in women with PCOS (r2 = .46, P ≤ .001), but only with CFM in controls (r2 = .28, P < .001).CONCLUSIONS: Fibrin lysability was comparable in women with PCOS and controls. Fibrin lysability was associated with CFM and hyper-inflammation in women with PCOS, but only with CFM in controls. These findings suggest that obese women with PCOS and augmented inflammation could have an increased risk of cardiovascular disease.
- Subjects :
- Adult
medicine.medical_specialty
obesity
Adolescent
Plasmin
medicine.medical_treatment
Fibrinogen
Fibrin
03 medical and health sciences
chemistry.chemical_compound
Absorptiometry, Photon
0302 clinical medicine
Sex hormone-binding globulin
Risk Factors
Internal medicine
Fibrinolysis
medicine
Humans
030212 general & internal medicine
confounding factors
fibrin
Gonadal Steroid Hormones
Inflammation
030219 obstetrics & reproductive medicine
biology
business.industry
Obstetrics and Gynecology
General Medicine
Polycystic ovary
Endocrinology
chemistry
Cardiovascular Diseases
inflammation
polycystic ovary syndrome
Case-Control Studies
Obesity, Abdominal
Hemostasis
Plasminogen activator inhibitor-1
biology.protein
hemostasis
Female
fibrinolysis
business
Biomarkers
Polycystic Ovary Syndrome
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Godtfredsen, A C M, Sidelmann, J J, Gram, J B, Skovsager Andersen, M & Glintborg, D 2020, ' Fibrin lysability is associated with central obesity and inflammation in women with polycystic ovary syndrome ', Acta Obstetricia et Gynecologica Scandinavica, vol. 99, no. 8, pp. 1078-1084 . https://doi.org/10.1111/aogs.13825
- Accession number :
- edsair.doi.dedup.....b3f827d19b750426b2d25d4cd499fcdb