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Multicentric, prospective observational data show sperm capacitation predicts male fertility, and cohort comparison reveals a high prevalence of impaired capacitation in men questioning their fertility
- Source :
- Reproductive BioMedicine Online. 41:69-79
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Can a previously defined relationship between sperm capacitation and the probability of a man generating pregnancy within three cycles, prospectively predict male fertility in diverse clinical settings? A second study asked, what is the prevalence of impaired sperm fertilizing ability in men questioning their fertility (MQF), and does this relate to traditional semen analysis metrics?In the multicentric, prospective observational study, data (n = 128; six clinics) were analysed to test a published relationship between the percentage of fertilization-competent, capacitated spermatozoa (Cap-Score) and probability of generating pregnancy (PGP) within three cycles of intrauterine insemination. Logistic regression of total pregnancy outcomes (n = 252) assessed fit. In the cohort comparison, Cap-Scores of MQF (n = 2155; 22 clinics) were compared with those of 76 fertile men.New outcomes (n = 128) were rank-ordered by Cap-Score and divided into quintiles (25-26 per group); chi-squared testing revealed no difference between predicted and observed pregnancies (P = 0.809). Total outcomes (n = 252; 128 new + 124 previous) were pooled and the model recalculated, yielding an improved fit (P0.001). Applying the Akaike information criterion found that the optimal model used Cap-Score alone. Cap-Scores were performed on 2155 men (with semen analysis data available for 1948). To compare fertilizing ability, men were binned by PGP (≤19%, 20-29%, 30-39%, 40-49%, 50-59%, ≥60%). Distributions of PGP and the corresponding Cap-Scores were significantly lower in MQF versus fertile men (P0.001). Notably, 64% of MQF with normal volume, concentration and motility (757/1183) had PGP of 39% or less (Cap-Scores ≤31), versus 25% of fertile men.Sperm capacitation prospectively predicted male fertility. Impaired capacitation affects many MQF with normal semen analysis results, informing diagnosis versus idiopathic infertility.
- Subjects :
- Male
0301 basic medicine
Infertility
medicine.medical_specialty
Pregnancy Rate
media_common.quotation_subject
Fertility
Semen analysis
Logistic regression
03 medical and health sciences
0302 clinical medicine
Pregnancy
Capacitation
medicine
Humans
Prospective Studies
Infertility, Male
media_common
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
Obstetrics
business.industry
Obstetrics and Gynecology
medicine.disease
Spermatozoa
Sperm
Semen Analysis
030104 developmental biology
Reproductive Medicine
Fertilization
Sperm Motility
Female
Observational study
business
Sperm Capacitation
Developmental Biology
Subjects
Details
- ISSN :
- 14726483
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Reproductive BioMedicine Online
- Accession number :
- edsair.doi.dedup.....b3f85e96b276ffb965acdc87d865c919
- Full Text :
- https://doi.org/10.1016/j.rbmo.2020.03.011