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Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 20, Iss 21, p 5435 (2019)
- Publication Year :
- 2019
-
Abstract
- Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity.
- Subjects :
- 0301 basic medicine
Review
medicine.disease_cause
Salivary Glands
Autoimmunity
lcsh:Chemistry
Pathogenesis
0302 clinical medicine
cytokine
Sjogren syndrome
lcsh:QH301-705.5
innate immunity
Spectroscopy
autoimmunity
Lacrimal Apparatus
General Medicine
Natural killer T cell
Computer Science Applications
Sjogren's Syndrome
iNKT
Catalysis
Inorganic Chemistry
03 medical and health sciences
Glycolipid
Immune system
Antigen
stomatognathic system
Rheumatic Diseases
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
030203 arthritis & rheumatology
Autoimmune disease
Innate immune system
business.industry
Organic Chemistry
medicine.disease
Immunity, Innate
cytokines
Settore MED/16 - Reumatologia
stomatognathic diseases
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Immunology
Natural Killer T-Cells
Glycolipids
business
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 20
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....b3fd00bf2ce0c178da59b29b2b08d6a9