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Towards optimal patient selection for bronchial thermoplasty treatment in severe asthma
- Source :
- European Respiratory Journal, 54. EUROPEAN RESPIRATORY SOC JOURNALS LTD
- Publication Year :
- 2019
-
Abstract
- Background: Bronchial Thermoplasty (BT) is a treatment for severe uncontrolled asthma patients. Although studies have shown clinical improvement after BT, not all patients respond equally well. Identifying optimal candidates for BT treatment is needed. Aim: To identify patient characteristic differences between BT responders and non-responders. Methods: Patients from the multicenter TASMA trial were included in this analysis. Before BT, a set of clinical, functional, inflammatory and airway biopsy data were collected (Table 1). A positive BT response was defined as a minimal clinically important change of >0.5 on asthma control questionnaire (ACQ) score, 6 months after BT. Results: 30 patients were analyzed. ACQ improved from 2.66 (±0.68) to 2.09 (±1.07) (p Conclusion: IgE and blood eosinophils before BT were higher in BT responders compared to non-responders and might therefore contribute in optimizing patient selection for BT.
- Subjects :
- medicine.medical_specialty
Severe asthma
Bronchial thermoplasty
biology
medicine.diagnostic_test
business.industry
Immunoglobulin E
law.invention
Uncontrolled asthma
Asthma - management
Randomized controlled trial
Asthma Control Questionnaire
law
Internal medicine
Biopsy
Bronchoscopy
biology.protein
medicine
business
Airway
Subjects
Details
- Language :
- English
- ISSN :
- 09031936
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....b402763fd730989c8aff1dca431213e9