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Bioinformatics analysis and genetic polymorphisms in genomic region of the bovine SH2B2 gene and their associations with molecular breeding for body size traits in qinchuan beef cattle
- Source :
- Bioscience Reports
- Publication Year :
- 2019
-
Abstract
- The Src homology 2 B 2 (SH2B2) gene regulate energy balance and body weight at least partially by enhancing Janus kinase-2 (JAK2)-mediated cytokine signaling, including leptin and/or GH signaling. Leptin is an adipose hormone that controls body weight. The objective of the present study is to evaluate the association between body measurement traits and SH2B2 gene polymorphisms as responsible mutations. For this purpose, we selected four single-nucleotide polymorphisms (SNPs) in SH2B2 gene, including two in intron 5 (g.20545A>G, and g.20570G>A, one synonymous SNP g.20693T>C, in exon 6 and one in intron 8 (g.24070C>A, and genotyped them in Qinchuan cattle. SNPs in sample populations were in medium polymorphism level (0.250A, g.20693T>C, and g.24070C>A, significantly (P < 0.05) associated with body length (BL) and chest circumference (CC) in Qinchuan cattle. In addition, H4H3 and H5H5 diplotype had highly significantly (P < 0.01) greater body length (BL), rump length (RL), and chest circumference (CC) than H4H2. Our investigation will not only extend the spectrum of genetic variation of bovine SH2B2 gene, but also provide useful information for the marker assisted selection in beef cattle breeding program.
- Subjects :
- 0301 basic medicine
Genotype
Bioinformatics
Qinchuan cattle
SH2B2 Gene
Biophysics
Adipose tissue
Single-nucleotide polymorphism
Beef cattle
Biology
Breeding
Biochemistry
Polymorphism, Single Nucleotide
body measurement
polymorphism
03 medical and health sciences
Exon
0302 clinical medicine
Gene Frequency
Genetic variation
Animals
Body Size
Molecular Biology
Gene
Alleles
Genetic Association Studies
Research Articles
Adaptor Proteins, Signal Transducing
Genetics
Gene Expression & Regulation
Leptin
Body Weight
Computational Biology
Cell Biology
Genomics
Sequence Analysis, DNA
Marker-assisted selection
030104 developmental biology
Haplotypes
030220 oncology & carcinogenesis
Cattle
Subjects
Details
- ISSN :
- 15734935
- Volume :
- 40
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Bioscience reports
- Accession number :
- edsair.doi.dedup.....b45d8d824e77d2b76eeec388c892e7e9