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Ziprasidone versus olanzapine, risperidone or quetiapine in patients with chronic schizophrenia: a 12-week open-label, multicentre clinical trial
- Source :
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 10(4 Pt 3)
- Publication Year :
- 2008
-
Abstract
- The efficacy, safety and tolerability of ziprasidone versus the comparators olanzapine, risperidone or quetiapine were investigated in adult patients with chronic schizophrenia, schizoaffective and schizophreniform disorders, with lack of efficacy or intolerance to their previous antipsychotic treatment based on clinical judgement of the investigator. A total of 293 patients were randomized to 12 weeks treatment with either ziprasidone 80-160 mg/day (n=147) or with one of the comparator drugs (n=146). In the latter group the investigator could choose between olanzapine 10-20 mg/day (n=24), risperidone 4-8 mg/day (n=22) or quetiapine 300-750 mg/day (n=97). The study comprised four visits including a baseline examination prior to randomization and further examinations at the end of weeks 1, 4 and 12. Ziprasidone was non-inferior (defined as a difference of 7 units or less on the PANSS scale to the disadvantage of ziprasidone) to the composite group (olanzapine, risperidone or quetiapine) on the total PANSS score as well as on all subscores (P
- Subjects :
- Olanzapine
Adult
Male
medicine.medical_specialty
Dibenzothiazepines
Randomization
Adolescent
Pharmacology
Piperazines
law.invention
Benzodiazepines
Quetiapine Fumarate
Young Adult
Randomized controlled trial
law
Internal medicine
medicine
Humans
Ziprasidone
Biological Psychiatry
Triglycerides
Aged
Risperidone
business.industry
Drug Tolerance
Middle Aged
Prolactin
Psychiatry and Mental health
Thiazoles
Cholesterol
Tolerability
Chronic Disease
Schizophrenia
Quetiapine
Female
business
medicine.drug
Antipsychotic Agents
Subjects
Details
- ISSN :
- 18141412
- Volume :
- 10
- Issue :
- 4 Pt 3
- Database :
- OpenAIRE
- Journal :
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....b46ed76ebcc023f02e66663a1bd70ed9