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Wenshen Yangxue decoction improves endometrial receptivity recovery and promotes endometrial angiogenesis in a rat model
- Source :
- Pharmaceutical Biology, Vol 56, Iss 1, Pp 573-579 (2018), Pharmaceutical Biology
- Publication Year :
- 2019
-
Abstract
- Context: Wenshen Yangxue decoction (WSYXD) is a famous traditional Chinese medicine (TCM) formula and has been used in infertility treatment, but the exact mechanism is still unknown. Objectives: To determine if WSYXD improves endometrial receptivity recovery and promotes endometrial angiogenesis in a rat model. Materials and methods: A total of 100 proestrus female SPF Wistar rats were randomly assigned into five groups: control (saline), model (saline and hydroxyurea solution), high (5.2/100 g), middle (2.6/100 g) and low (1.3/100 g) WSYXD dose groups for 10 d. The microvessel densities, endometrial microstructure, as well as blastocysts number, were observed, followed by detection of angiogenesis-related gene/protein expression by immunohistochemistry, western blot and quantitative real-time polymerase chain reaction (RT-PCR), respectively. Results: Compared with the model group, the blastocyst number in WSYXD middle and high groups were significantly increased (4.50 ± 3.11 vs. 13.00 ± 2.12, 14.00 ± 1.83, p
- Subjects :
- 0301 basic medicine
Oncology
Infertility
medicine.medical_specialty
Angiogenesis
Rat model
Pharmaceutical Science
Neovascularization, Physiologic
Context (language use)
Decoction
Traditional Chinese medicine
03 medical and health sciences
Endometrium
Random Allocation
0302 clinical medicine
microvessel density
Internal medicine
Drug Discovery
Medicine
Animals
Rats, Wistar
pi3k
vegf
Microvessel density
Pharmacology
030219 obstetrics & reproductive medicine
business.industry
lcsh:RM1-950
General Medicine
Recovery of Function
medicine.disease
Rats
030104 developmental biology
lcsh:Therapeutics. Pharmacology
Complementary and alternative medicine
Models, Animal
hif-1α
Molecular Medicine
Female
Endometrial receptivity
business
Research Article
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 17445116
- Volume :
- 56
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical biology
- Accession number :
- edsair.doi.dedup.....b47071fa64cbbc9a756d2682baa97b28