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Hepatoprotective effect of Hypericum japonicum extract and its fractions
- Source :
- Journal of ethnopharmacology. 116(1)
- Publication Year :
- 2006
-
Abstract
- Objective To investigate the hepatoprotective activity of different parts of Hypericum japonicum against carbon tetrachloride(CCl 4 )-induced hepatitis and α-naphthyl-isothiocyanate (ANIT)-induced cholestasis. Materials and Methods Mice were divided into groups and then administrated orally with solutions extracted from herbs before they were modeled in the experiments. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (T-BIL) in serum were evaluated. HPLC fingerprint was used for phytochemical analysis of the extracts. Results The total aqueous extract of Hypericum japonicum had an obvious effect on the decreasing of AST, ALT and T-BIL levels in serum. The isolated fraction IV (F4) exhibited a preferable activity of ameliorating cholestasis, while Fraction V (F5) was more efficacious in protecting liver from injury. Chemical fingerprint indicated that F5 contained several flavonoids which might be the active chemicals against hepatotoxicity. Conclusion Different fractions of Hypericum japonicum manifest different effect, indicating their different potentials as candidacies of new drugs.
- Subjects :
- Male
Bilirubin
Cholestasis, Intrahepatic
Pharmacognosy
Protective Agents
Hplc fingerprint
chemistry.chemical_compound
Mice
Cholestasis
Drug Discovery
medicine
Animals
Aspartate Aminotransferases
Carbon Tetrachloride
Chromatography, High Pressure Liquid
Pharmacology
Hepatitis
Traditional medicine
Hypericum japonicum
business.industry
Plant Extracts
Alanine Transaminase
medicine.disease
chemistry
Phytochemical
Liver
Carbon tetrachloride
Female
business
Hypericum
Subjects
Details
- ISSN :
- 03788741
- Volume :
- 116
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of ethnopharmacology
- Accession number :
- edsair.doi.dedup.....b486ae51dfe40ec9ed885689e341f4de