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Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction
- Source :
- Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020), Communications Biology
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Upon severe and/or chronic liver injury, ectopic emergence and expansion of atypical biliary epithelial-like cells in the liver parenchyma, known as the ductular reaction, is typically induced and implicated in organ regeneration. Although this phenomenon has long been postulated to represent activation of facultative liver stem/progenitor cells that give rise to new hepatocytes, recent lineage-tracing analyses have challenged this notion, thereby leaving the pro-regenerative role of the ductular reaction enigmatic. Here, we show that the expanded and remodelled intrahepatic biliary epithelia in the ductular reaction constituted functional and complementary bile-excreting conduit systems in injured parenchyma where hepatocyte bile canalicular networks were lost. The canalicular collapse was an incipient defect commonly associated with hepatocyte injury irrespective of cholestatic statuses, and could sufficiently provoke the ductular reaction when artificially induced. We propose a unifying model for the induction of the ductular reaction, where compensatory biliary epithelial tissue remodeling ensures bile-excreting network homeostasis.<br />Kenji Kamimoto et al. use multidimensional imaging technologies to study changes in the mouse biliary system following liver injury. They find an unexpected role of the ductular reaction – the process of ectopic expansion of biliary-like cells following liver injury – in restoring functional biliary structures in injured livers.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Organogenesis
Medicine (miscellaneous)
digestive system
Article
General Biochemistry, Genetics and Molecular Biology
Mice
03 medical and health sciences
0302 clinical medicine
Parenchyma
medicine
Animals
Regeneration
Bile ducts
Progenitor cell
lcsh:QH301-705.5
Organ regeneration
Mice, Knockout
Adult stem cells
Liver injury
Chemistry
Regeneration (biology)
Epithelial Cells
medicine.disease
digestive system diseases
Mice, Inbred C57BL
Disease Models, Animal
Bile Ducts, Intrahepatic
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
Hepatocyte
Hepatocytes
Female
030211 gastroenterology & hepatology
Chemical and Drug Induced Liver Injury
General Agricultural and Biological Sciences
Homeostasis
Adult stem cell
Subjects
Details
- ISSN :
- 23993642
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Communications Biology
- Accession number :
- edsair.doi.dedup.....b4a2129b74be58d9f4daed91f378df1d