Assessing the Combinatorial Chemo‐Photothermal Therapy Mediated by Sulfobetaine Methacrylate‐Functionalized Nanoparticles in 2D and 3D In Vitro Cancer Models

Combinatorial cancer therapies mediated by nanomaterials can potentially overcome the limitations of conventional treatments. These therapies are generally investigated using 2D in vitro cancer models, leading to an inaccurate screening. Recently, 3D in vitro spheroids have emerged in the pre-clinical testing stage of nanomedicines due to their ability to mimic key features of the in vivo solid tumors.
CENTRO-01-0145-FEDER-028989; POCI-01- 0145-FEDER-031462; POCI-01-0145-FEDER-007491