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Comparison of efficacy and safety between simultaneous integrated boost intensity-modulated radiotherapy and conventional intensity-modulated radiotherapy in locally advanced non-small-cell lung cancer: a retrospective study
- Source :
- Radiation Oncology (London, England), Radiation Oncology, Vol 14, Iss 1, Pp 1-9 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Consistent results are lacking as regards the comparative effectiveness of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus conventional intensity-modulated radiotherapy in patients with locally advanced non-small-cell lung cancer (LA-NSCLC). Therefore, we conducted a retrospective analysis to demonstrate the role of SIB-IMRT for patients. Methods Patients who had histologically confirmed NSCLC, stage III disease and received thoracic IMRT between 2014 and 2016 were retrospectively reviewed. The survival, toxicities and dose to organs at risk (OAR) were compared among patients irradiated with different techniques. The SIB-IMRT plans were designed to deliver 45–59.4Gy (median: 50.4Gy) to PTV while simultaneously delivering 50-70Gy (median: 59.92Gy) to PGTV. As for conventional IMRT plans, a total dose of 50-70Gy (median: 60Gy) was delivered to PTV. Results 426 patients with stage III NSCLC were eligible for analysis, including 128 with SIB-IMRT and 298 with conventional IMRT. The SIB-IMRT group had more stage IIIB disease (69.5% vs. 53%, P = 0.002), larger planning treatment volumes (median: 504 ml vs. 402 ml, P
- Subjects :
- Male
Organs at Risk
Lung Neoplasms
Survival
medicine.medical_treatment
0302 clinical medicine
Non-small cell lung cancer
Carcinoma, Non-Small-Cell Lung
Simultaneous integrated boost
Stage (cooking)
Aged, 80 and over
Radiotherapy Dosage
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Survival Rate
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Female
Radiology
Intensity modulated radiotherapy
therapeutics
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
medicine.medical_specialty
Intensity-modulated radiotherapy
lcsh:R895-920
Locally advanced
lcsh:RC254-282
03 medical and health sciences
otorhinolaryngologic diseases
medicine
Humans
Radiology, Nuclear Medicine and imaging
Lung cancer
neoplasms
Aged
Retrospective Studies
Lung
Toxicity
business.industry
Radiotherapy Planning, Computer-Assisted
Research
Retrospective cohort study
medicine.disease
Radiation therapy
stomatognathic diseases
Radiotherapy, Intensity-Modulated
business
Subjects
Details
- ISSN :
- 1748717X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology
- Accession number :
- edsair.doi.dedup.....b4ae8ad9f184e3165896bef7c766e6dc