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Left Ventricular Non-Compaction
- Source :
- Journal of the American College of Cardiology. 46(1):101-105
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- OBJECTIVES We aimed to test the diagnostic accuracy of cardiovascular magnetic resonance (CMR) imaging in distinguishing pathological left ventricular non-compaction (LVNC) from lesser degrees of trabecular layering seen in healthy volunteers and, in those with cardiomyopathies and concentric left ventricular hypertrophy, potential differential diagnoses. We hypothesized that pathological trabeculation could be distinguished by determining the ratio of non-compacted to compacted myocardium (NC/C ratio). BACKGROUND Left ventricular non-compaction is characterized by a non-compacted myocardial layer in the left ventricle. Cardiovascular magnetic resonance images this layer with unprecedented quality, particularly in the ventricular apex, where echocardiography has inherent difficulties. METHODS We analyzed magnetic resonance cine images, using the 17-segment model in 45 healthy volunteers, 25 athletes, 39 patients with hypertrophic cardiomyopathy and 14 with dilated cardiomyopathy, 17 with hypertensive heart disease, and 30 with aortic stenosis, as well as images from 7 patients previously diagnosed with LVNC whose diagnoses were supported by additional features. RESULTS Areas of non-compaction were common and occurred more frequently in all groups studied in apical and lateral, rather than in basal or septal, segments. A NC/C ratio of >2.3 in diastole distinguished pathological non-compaction, with values for sensitivity, specificity, and positive and negative predictions of 86%, 99%, 75%, and 99%, respectively. CONCLUSIONS Left ventricular non-compaction is diagnosed accurately with CMR using the NC/C ratio in diastole.
- Subjects :
- medicine.medical_specialty
business.industry
Diastole
Cardiomyopathy
Hypertrophic cardiomyopathy
Dilated cardiomyopathy
030204 cardiovascular system & hematology
Left ventricular hypertrophy
medicine.disease
Left ventricular noncompaction cardiomyopathy
3. Good health
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Internal medicine
Aortic valve stenosis
Cardiology
medicine
cardiovascular system
Left ventricular noncompaction
Radiology
business
Cardiology and Cardiovascular Medicine
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 46
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....b4b0971f640dac36bfdc980217cd0b4b
- Full Text :
- https://doi.org/10.1016/j.jacc.2005.03.045