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A comparison of serum and sputum inflammatory mediator profiles in patients with asthma and COPD
- Source :
- The Journal of international medical research. 40(6)
- Publication Year :
- 2013
-
Abstract
- Objective: To investigate serum and sputum cytokine profiles in asthma and chronic obstructive pulmonary disorder (COPD). Methods: Clinical characteristics, blood and sputum samples were collected from asthma (n = 37) and COPD (n = 36) patients, and healthy subjects (n = 39). Cytokines were measured by enzyme-linked immunosorbent assay (ELISA) and inflammation antibody array; levels were analysed according to smoking status and presence of eosinophilia in the airways of COPD/asthma patients, and compared with those in healthy subjects. Results: ELISA revealed a significant difference in the expression of only a few cytokines in the COPD versus asthma groups, and in both patient groups compared with healthy subjects. The antibody array showed greater differentiation in inflammatory mediators. In the subphenotype analysis, the differential expression of cytokines was more significant between eosinophilic and noneosinophilic airway inflammation than between asthma and COPD, according to both the ELISA and antibody array. There was little difference in cytokine expression between smoking and nonsmoking subgroups. Conclusions: Differential expression of inflammatory mediators is present between patients with COPD or asthma, and eosinophilic or noneosinophilic airway inflammation, and contributes to understanding the cytokine network of airway inflammation.
- Subjects :
- Male
medicine.medical_treatment
Inflammation
Enzyme-Linked Immunosorbent Assay
Biochemistry
Pulmonary Disease, Chronic Obstructive
Eosinophilic
Eosinophilia
medicine
Humans
Asthma
Aged
COPD
business.industry
Biochemistry (medical)
Smoking
Sputum
Cell Biology
General Medicine
Pneumonia
Middle Aged
medicine.disease
respiratory tract diseases
Cytokine
Immunology
Cytokines
Female
medicine.symptom
Inflammation Mediators
business
Subjects
Details
- ISSN :
- 14732300
- Volume :
- 40
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Journal of international medical research
- Accession number :
- edsair.doi.dedup.....b4ce0b040b21a5fac5248c1a74c27826