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Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity
- Source :
- European Cells & Materials, 36, European Cells & Materials, Vol 36, Pp 231-250 (2018)
- Publication Year :
- 2018
- Publisher :
- AO Research Institute Davos, 2018.
-
Abstract
- Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity response-element-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)] in healthy and degenerated IVDs. Finally, an overview of the potential therapeutic targets for modifying osmosensing and osmosignalling in degenerated IVDs is provided.<br />European Cells & Materials, 36<br />ISSN:1473-2262
- Subjects :
- lcsh:Diseases of the musculoskeletal system
transient receptor potential channel
lcsh:Surgery
osmotic
IVD
inflammatory
lcsh:RD1-811
degenerative disc disease
Intervertebral disc degeneration
osmolarity
Transient receptor potential channels (TRP)
tonicity-responsive enhancer binding protein
aquaporin
540 Chemie und zugeordnete Wissenschaften
hyper-osmolarity
lcsh:RC925-935
610 Medizin und Gesundheit
hypo-osmolarity
Subjects
Details
- Language :
- English
- ISSN :
- 14732262
- Database :
- OpenAIRE
- Journal :
- European Cells & Materials, 36, European Cells & Materials, Vol 36, Pp 231-250 (2018)
- Accession number :
- edsair.doi.dedup.....b4e4868d07bd67e9c2268d9b39d58bba