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Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice
- Source :
- Neuroscience research. 147
- Publication Year :
- 2018
-
Abstract
- Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels.
- Subjects :
- 0301 basic medicine
congenital, hereditary, and neonatal diseases and abnormalities
Dopamine and cAMP-Regulated Phosphoprotein 32
Microarray
Mutant
Gene Expression
Mice, Transgenic
In situ hybridization
Biology
Medium spiny neuron
03 medical and health sciences
Mice
0302 clinical medicine
mental disorders
Gene expression
Animals
Humans
Gene
In Situ Hybridization
Neurons
General Neuroscience
Brain
General Medicine
Non-coding RNA
Corpus Striatum
nervous system diseases
Cell biology
Disease Models, Animal
030104 developmental biology
Huntington Disease
nervous system
RNA, Long Noncoding
Serine Proteases
Transcriptome
030217 neurology & neurosurgery
Intracellular
Subjects
Details
- ISSN :
- 18728111
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- Neuroscience research
- Accession number :
- edsair.doi.dedup.....b4e69671db7722aa32c81b14a912563e